What is the buzz on Hydroxysomes – what does it do, and how does it work?

Hydroxysomes help repair damaged skin, improve skin integrity, increase skin flexibility and rejuvenation, and reduce the appearance of fine lines and wrinkles. There are no penetration enhancers needed due to the delivery system. A patented microcarrier delivery system is what makes Hydroxysomes unique and effective. It is the newest, most advanced dermal delivery platform made of calcium and inorganic phosphate (non-nano) particles. This dermal delivery system effectively targets specific skin concerns in skin care products, making formulations to be effective. The effective dermal delivery system allows innovative actives to penetrate into the skin and remain stable. Though trademarked and licensed, this technology allows pharmaceutical and biotechnology companies, as well as cosmetic companies, a vehicle for new actives and drugs to improve the absorption and effectiveness of their skin care products.


Repairing damaged skin

Hydroxysomes stimulate skin cells to produce elastin and collagen, activate skin cell regeneration by accelerating barrier recovery, and improve firmness, cellular cohesion and hydration to help repair damaged skin. How does this work if there are no penetration enhancers? The calcium phosphate starting material comes from natural mines, which is then developed into secondary uniform particles by mechanical engineering and not chemical engineering. These particles are 100% biocompatible and biodegradable. The technology of the delivery system allows Hydroxysomes to be co-engineered with many classes of cosmetic actives or pharmaceutical actives, including proteins and peptides. That makes this a very lucrative market opportunity to consider due to the chemical nature, molecular weight limitations or instability issues.

Hydroxysomes ionically attach to the bioactives throughout the inner pores and the outer surface of the particles. They are released because of the natural skin pH gradient in the stratum corneum, which is 4.5 to 4.7 in the middle of the stratum corneum region. The particles remain localized in this region, and as they dissociate in the lower pH of the skin, the bioactives are released over time in sustained release manner.


What role does calcium play?

A major benefit of Hydroxysome particles is delivery of calcium into the skin. This means that every time you are delivering a bioactive with Hydroxysome, you are also delivering calcium. Why is calcium important? Loss of calcium and its properties within the skin occurs as we age, and as a result, the skin becomes more fragile, dehydrated, detached and less resistant to environmental damage. Calcium is the actual signal to trigger keratinocyte differentiation, which accelerates rapid skin cell generation. There are studies that show when skin is damaged, the calcium gradient is not present; it appears as the skin starts to repair itself as it regenerates. It restores and is solely responsible for skin cell regeneration. Calcium is becoming a keyword when referring to skin care treatments and cellular renewal. This is what makes Hydroxysomes unique – it is the sustained release; the dermal delivery system allows delivery to happen slowly over hours using the natural skin pH. The active ingredients are delivered into the skin over time like a patch you would have on your skin, but this is patchless patch. Think of it as a virtual patch inside the stratum corneum rather than an actual patch outside the skin – actives are time released.


The sky is the limit when it comes to exploring active ingredients combined with Hydroxysomes.

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